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Hypertension Research Network

Work-packages 2: Kidney

WP2. Contribution of the kidney to resistant hypertension

Prof. Dr. Johannes Loffing and Prof. Dr. Carsten A. Wagner

The kidneys are central for long-term blood pressure control. Enhanced renal salt retention significantly contributes to the development of arterial hypertension. The activity of renal salt transporting proteins correlates with the excretion of these proteins in urinary exosomes. We take advantage of our previous work to develop and implement novel enzyme-linked immunosorbent assays for an easy quantification of ion transport proteins in human urine to improve the clinical stratification of hypertensive patients. Moreover, we use appropriate mouse models to validate our findings made in patients and to address underlying cellular and molecular mechanism for resistant hypertension.